Project Sleep Attends World Sleep 2025 in Singapore

Project Sleep President and CEO, Julie Flygare, and Project Sleep Board Member, Stephanie Manuli, traveled to Singapore to attend and speak at the 2025 World Sleep Congress, which took place September 5-10, 2025. Project Sleep was honored to take part in this global gathering of over 4,000 sleep researchers and clinicians from around the world.

From presenting patient stories and advocacy perspectives to conversations about narcolepsy awareness, LGBTQ+ sleep health, brain fog, and diagnostic delays-—we were proud to bring patient voices and Project Sleep’s work to the forefront. Between Flygare and Manuli, they participated in seven sessions during the conference.

Project Sleep was especially thrilled to be present for the historic clinical trial results shared for orexin agonists. Takeda unveiled Phase 3 data for oveporexton (TAK-861) showing remarkable improvements in wakefulness, cataplexy, symptom severity, and quality of life for people with narcolepsy type 1. Alkermes also reported positive Phase 2 Vibrance-1 results for alixorexton, demonstrating clinically meaningful gains in wakefulness, cognition, and fatigue—all with once-daily dosing.

We left inspired by meaningful conversations and advancements that will shape the future of sleep health and equity worldwide. Thank you to everyone who connected with us during this unforgettable event! See photos and more below.

Project Sleep’s World Sleep 2025 Schedule

Saturday, September 6, 4:15–5 p.m.: Julie Flygare presented “Living with narcolepsy: A patient’s voice” during Understanding narcolepsy: A comprehensive clinical update

Sunday, September 7, 3:40–4 p.m.: Julie Flygare presented “From isolation to international narcolepsy awareness: The power of peers and role models to build a global movement” during Narcolepsy and other hypersomnias of central origin: From mechanism to management

Monday, September 8, 5:34–5:50 p.m.: Stephanie Manuli presented “The role of social outcomes from patient perspective” during Social and neuropsychological outcomes in central disorders of hypersomnolence

Tuesday, September 9, 3:15–4:45 p.m.: Julie Flygare represented the United States in Discussion group: Global perspectives on sleep health advocacy: Insights and experiences across five continents

Flygare participated in a discussion group that provided a platform for sharing perspectives and experiences on sleep health advocacy work spanning five continents. To foster open discussions, a panel of clinicians, scientists, and a patient representative shared perspectives from Iran, the UK, Nigeria, the USA, Australia, and Canada. These brief presentations explored challenges and advancements in sleep medicine and highlighted how sleep health intersects with broader public health issues. Learn more.

Tuesday, September 9, 4:45–5:45 p.m.: Stepanie Manuli presented the poster “Sleeping while Queer: Impacts of sexual and gender identity-related concerns on sleep health in the LGBTQ+ community before and after the 2025 US presidential inauguration”

On Tuesday, September 9 from 4:45–5:45 p.m., Manuli presented a poster on the impact of sexual and gender identity-related concerns on sleep health in the LGBTQ+ community before and after the 2025 US Presidential inauguration. Learn more.

This study finds that LGBTQ+ community members are experiencing significantly higher rates of minority stress-related sleep issues than before the 2025 US presidential inauguration. These differences may be linked to a post-inauguration increase in federal anti-LGBTQ+ policies and presidential executive orders. Overall, this study provides valuable insights into factors negatively impacting sleep health in LGBTQ+ communities following the 2025 inauguration and highlights distinct differences between the impacts on transgender and nonbinary individuals and their cisgender counterparts. Learn more about the LGBTQ+ Sleep Survey conducted by Project Sleep.

Wednesday, September 10, 9:22–9:42 a.m.: Julie Flygare presented “Navigating brain fog: Patient experience of cognitive challenges in the real world” during Cognitive symptoms in narcolepsy and idiopathic hypersomnia: Neurobiology, functional impact, and clinical research

Wednesday, September 10, 4:19–4:35 p.m.: Julie Flygare presented “A patient’s perspective and mission to reduce delays” during World clock: Turning back time on diagnostic delays in NT1

World Sleep 2025 Photo Album

World Sleep 2025: Learn More

The full scientific and clinical program for World Sleep 2025 is available online. Explore keynote speakers, symposia, and full session details in the interactive schedule. Sign up for email notifications and check back on worldsleepcongress.com for more updates!